This document is a CARPHA Situational Awareness Update (SA-Rep), Issue #2, dated 28 May 2026, providing an overview of emerging global public health threats and their potential implications for the Caribbean. The report focuses primarily on the ongoing Ebola Virus Disease outbreak in the Democratic Republic of the Congo and Uganda, which was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization. It summarizes the epidemiological situation, transmission trends, risk assessments, and regional preparedness measures, while emphasizing that the current risk to the Caribbean remains low. The update also outlines CARPHA’s surveillance, travel screening, and monitoring activities, and highlights additional events under observation, including an Andes hantavirus cluster associated with a cruise ship in Argentina and a norovirus outbreak on a cruise ship in France. Overall, the document serves as a strategic situational awareness and risk assessment tool to support public health preparedness and response across the Caribbean region.